李默怡

发布者：吴志龙发布时间：2020-09-08浏览次数：6388

   


 


李默怡     副教授、博士生导师                  

 电  话：

 Email: limoyi@seu.edu.cn

办公地点：李文正楼南204



个人简介：

1996年9月 — 2000年6月    学士， 微生物专业，华中农业大学

2000年9月 — 2003年6月    硕士， 生化工程专业，华中科技大学

2003年8月 — 2008年5月    博士， 植物病理专业，佛罗里达大学

2009年1月 — 2013年7月    博士后，佛罗里达大学

2014年1月 — 2016年2月    博士后，8455新葡萄娱集团am

2016年2月至今               副研究员，8455新葡萄娱集团am


研究方向：

  1. 神经发育与退行性疾病的分子机理

  2. 环路发育及功能的遗传控制机制


近期代表性论文：

  1. Li M*#, Zhuang Y*, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W#. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. (2020) Proc. Natl. Acad. Sci. U.S.A. 117(10):5472-5477. * co-first author; # Co-corresponding author

  2. Xing G*, Li M* (co-first author), Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W.  Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457

  3. Liang X, Liberti D, Li M, Kim YT, Hutchens A, Wilson R, Rollins JA. Oxaloacetate acetylhydrolase gene mutants of Sclerotinia sclerotiorum do not accumulate oxalic acid, but do produce limited lesions on host plants. (2015) Mol. Plant Pathol. 16: 559-571.

  4. Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D J, Goodwin M, Zhang C, Sobczak K, Thornton C A., and Swanson MS. Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA Mediated Disease. (2014) Mol. Cell. 56: 311-322

  5. Lee KY*, Li M* (co-first author), Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900

  6. Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB and Swanson MS. Progressive impairment of muscle regeneration in muscleblind-like 3 Isoform knockout mice. (2013) Hum. Mol. Genet. 22: 3547-3558

  7. Warren SA, Briggs LE, Zeng H, Chuang J, Chang Eileen, Terada R, Li M, Swanson MS, Wood CE, Spinale FG, Maupine-Furlow J, McMullen JR, Moss R, Kasahara H. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. (2012) Circulation. 126: 2575-2588  

  8. Li M, Liang X, and Rollins JA. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420

  9. Li M and Rollins JA. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538

  10. Li M and Rollins JA. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43